This is interesting:High Dose Zinc Increases Hospital Admissions Due to Genitourinary Complications, The Journal of Urology, 2007
In this randomized, placebo-controlled study of 3,640 men and women:
"We found a significant increase in hospital admissions due to genitourinary causes in patients on zinc* vs nonzinc formulations."* Patients were taking 80 mg zinc/day.
"The risk was greatest in male patients."
The most common causes of hospital admission:
- Benign prostatic hyperplasia/urinary retention
- Urinary tract infection ("When comparing zinc to placebo, significant increases in urinary tract infections were found.")
- Urinary lithiasis (kidney stones)
- Renal failure
Conclusion:
"Zinc supplementation at high levels results in increased hospitalizations for urinary complications compared to placebo."
3 comments:
Interesting stuff; I poked around looking for a free version of the full study, but couldn't find anything.
I'd speculate that the high dose causes immunosupression specific to GU bacteria, perhaps through Cu depletion. 80mg is a shwackload to be taking---a standard ZMA dose is only 30mg, and I've been up-dosing my ZMA to 40mg/600mg/14mg Zn/Mg/B6 for a year now, with zero negative issues and a diet heavy on red meat.
Nonetheless, good info to know.
Well I'll be galvanized.
Ha.
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