A revisit of data in the huge Women’s Health Initiative (WHI) study found that women who took calcium supplements increased their risk for heart attack and stroke:
Calcium Supplements With Or Without Vitamin D And Risk Of Cardiovascular Events: Reanalysis Of The Women’s Health Initiative Limited Access Dataset And Meta-Analysis, British Medical Journal, April 2011
The original WHI analysis showed no such risk. But that was because thousands of women who were already taking calcium before the study weren't told to stop. If those calcium-takers ended up in the placebo group (which was supposed to receive no calcium), you might expect them to show similar heart attack risk as intervention groups (which did receive calcium). That's exactly what they found.
This new analysis looked at women who weren't taking calcium before the study. If those women were randomized to a group that received calcium, it did indeed increase their risk for heart attack and stroke.
The Amount Of Calcium Didn't Matter
Here's Dr. Ian Reid, senior author of the new analysis:
"It is actually taking a supplement that matters, not how much of it you take, that causes this increase in heart risk."And from a HeartWire interview:
"That makes sense, [Reid] says, since even small levels of supplemental calcium create "abrupt" increases in blood calcium levels within hours. This speaks to one criticism levied at the group's earlier work—namely, that the cardiovascular events seemed to be occurring too swiftly to be related to calcified plaques.I would like to add to those mechanisms something readers of this blog already know - calcium lowers vitamin D levels, and vitamin D is thought to be cardio-protective:
MI spikes likely reflect a more acute response to blood calcium levels, including changes in platelet function, blood coaguability, or endothelial cell activity."
- Calcium Supplements And Cardiovascular Events: New Data, More Debate, HeartWire, April 19, 2011
"If serum levels of calcium are high, production of 1, 25 D is suppressed by reduced parathyroid hormone production."The present analysis found no benefit in taking vitamin D.
- Dairy Products, Calcium, and Vitamin D and Risk of Prostate Cancer, Epidemiologic Reviews, 2001
"Our own recommendation is to critically review the use of calcium supplements, since the data in this paper suggests that they do more harm than good."
Women Taking Calcium Supplements May Risk Heart Health, Researchers Say, HealthDay, April 19, 2011
That's a photo of the pills I used to take, be still my heart. Wait.