Statin Use and Risk of Prostate Cancer: Results from a Population-based Epidemiologic Study, American Journal of Epidemiology, August 2008
Dairy food consumption is not alone in its link to prostate cancer. Add statins to the list - but only if the men who take them are overweight.
In this study, men with a BMI > 30 (Calculate your BMI here. A man 5'10", 209 lb has a BMI = 30.) who used statins had a 50% higher risk for prostate cancer than obese non-statin-users (so, it wasn't just because they were overweight). If obese men used statins for 5 years or more, that risk jumped to 80%.
Two mechanisms were put forth:
- Levels of a protein called sex hormone-binding globulin (SHBG) were found in a previous study to be lower in statin users; and a recent analysis of studies revealed that men with lower levels of SHBG were at higher risk of developing prostate cancer.
- Statins have been shown to increase the level of regulatory T-cells, "which may suppress antitumor T-cell response and thereby enhance cancer risk."