I geeked. 18 monts Post Paleo, first Blood-test Results, PaleoHacks, February 2011
These were his numbers after 18 months of his diet:
Fasted Blood Glucose - 93mg/dL
Cholesterol, Total - 377
Triglycerides - 86 mg/dL
HDL Cholesterol - 72 mg/dL
vLDL Calc - 17 mg/dL
LDL Calc - 288 mg/dL
25-Hydroxy - 62.8 ng/mL
A1C - 5.5
CRP - 0.75 mg/L
TSH - 2.150 uIU/mL
T4,Free(direct) - 1.2 ng/Dl
T3 - 69 ng/DL
He said he was eating:
"... a cyclical ketogenic paleo diet. I eat probably 70% store bought meat/30% grass-fed meat. I take a tablespoon fish oil when I eat the standard meat (works out to be 3-4grams of EPA/DHA). Other fat sources come from pastured butter, coconut, avocado, some olive oil (only as dressing)."A ketogenic diet, a diet that generates ketones, is a low-carbohydrate diet. If you are not eating much carbohydrate, you are eating mostly fat and protein, which jives with his meaty diet description.
I thought his total cholesterol, LDL cholesterol, and possibly his HDL (since high HDL is not always good) were high. I was surprised since he had recently lost weight (quite a bit, 22% of his former body weight, from 250 to 195), worked out regularly, and is in the youthful prime of his life, all factors that favor lower cholesterol numbers. Perhaps they are lower than his baseline numbers though, which aren't given.
There is one thing .. higher blood glucose tends to raise LDL because the LDL receptor, and the LDL particle itself, become coated in glucose.1 You can't clear these fats from your blood as easily. I saw that his fasting glucose and HbA1c are just a touch high. A high-fat diet is known to alter gut flora and increase insulin resistance, which can, by different mechanisms, result in higher blood glucose. Well, neither here nor there, is it ... I'm only speculating.
What I'm wondering ... Do Paleo diets typically result in higher cholesterol?
Photo from NPR: "Vlad Averbukh, 29, a follower of the paleo diet, eats raw meat along the Hudson River in New York in 2010."