Monday, November 01, 2010

Zinc Makes BPH (Benign Prostatic Hyperplasia) Worse?

This is interesting:
High Dose Zinc Increases Hospital Admissions Due to Genitourinary Complications, The Journal of Urology, 2007

In this randomized, placebo-controlled study of 3,640 men and women:
"We found a significant increase in hospital admissions due to genitourinary causes in patients on zinc* vs nonzinc formulations."

"The risk was greatest in male patients."

The most common causes of hospital admission:
  • Benign prostatic hyperplasia/urinary retention
  • Urinary tract infection ("When comparing zinc to placebo, significant increases in urinary tract infections were found.")
  • Urinary lithiasis (kidney stones)
  • Renal failure
* Patients were taking 80 mg zinc/day.

"Zinc supplementation at high levels results in increased hospitalizations for urinary complications compared to placebo."


Mike said...

Interesting stuff; I poked around looking for a free version of the full study, but couldn't find anything.

I'd speculate that the high dose causes immunosupression specific to GU bacteria, perhaps through Cu depletion. 80mg is a shwackload to be taking---a standard ZMA dose is only 30mg, and I've been up-dosing my ZMA to 40mg/600mg/14mg Zn/Mg/B6 for a year now, with zero negative issues and a diet heavy on red meat.

Nonetheless, good info to know.

Ronald said...

Well I'll be galvanized.

Bix said...